The risk of metabolic syndrome in polycystic ovary syndrome A systematic review and meta-analysis

The risk of metabolic syndrome in polycystic ovary syndrome

A systematic review and meta-analysis

Samira Behboudi-Gandevani, Mina Amiri, Razieh Bidhendi Yarandi,

Mahsa Noroozzadeh, Maryam Farahmand, Marzieh Rostami Dovom,

Fahimeh Ramezani Tehrani

Reproductive Endocrinology ResearchCenter, Research Institute for Endocrine

Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

INTRODUCTION

• Polycystic ovarian syndrome (PCOS) is one of the most common heterogeneous endocrine disorders that influence 7%-15% of women of reproductive age.
• It is characterized by chronic oligo-anovulation, clinical or biochemical signs of hyperandrogenism, not related to other causes of hyperanderogenism and polycystic ovaries morphology, based on the results of pelvic ultrasound
• The aetiology of PCOS is not completely understood.
• Waist Circumference
  • Greater than 35 inches in women and 40 inches in men (abdominal obesity)
  • Triglyceride
  • Levels of 150 milligrams per deciliter (mg/dl) or higher
  • Blood Pressure
  • 130/85 millimeters of mercury or higher
  • Fasting blood glucose
  • Level of 110 mg/dl or higher
  • High-density lipoprotein cholesterol (HDL)
  • Lower than 50 mg/dl in women

Women with PCOS had increased prevalence of MetS

All (OR 2.88, 95% CI 2.40, 3.45)

BMI-matched studies (OR 2.20, 95% CI 1.36, 3.56)